Formulation considerations for the development of high concentration biopharmaceuticals
This webinar discusses the challenges of developing high-concentration biopharmaceutical formulations, such as increased aggregation, viscosity, and opalescence. It also presents case studies on how to manage these issues and practical strategies for streamlining the formulation process, with a focus on enabling subcutaneous administration for patient convenience.
Key learning objectives:
- Understand challenges in developing high-concentration biopharmaceutical formulations.
- Discuss fundamental formulation principles and tools for successful high-concentration formulations.
- Explore Samsung Biologics’ practical strategies for developing high-concentration formulations.
- Small-scale tangential flow filtration to understand pH shift
- Small-scale spikes to understand feasibility of achieving spikes and provide final pH/osmolality of the final formulation
- Evaluation of screening methods for high-concentration formulations — HIAC dilution and SEC dilution
This webinar discusses the challenges of developing high-concentration biopharmaceutical formulations, such as increased aggregation, viscosity, and opalescence. It also presents case studies on how to manage these issues and practical strategies for streamlining the formulation process, with a focus on enabling subcutaneous administration for patient convenience.
Key learning objectives:
- Understand challenges in developing high-concentration biopharmaceutical formulations.
- Discuss fundamental formulation principles and tools for successful high-concentration formulations.
- Explore Samsung Biologics’ practical strategies for developing high-concentration formulations.
- Small-scale tangential flow filtration to understand pH shift
- Small-scale spikes to understand feasibility of achieving spikes and provide final pH/osmolality of the final formulation
- Evaluation of screening methods for high-concentration formulations — HIAC dilution and SEC dilution
- CDO
- CGMP
- ADC
- Bio Campus
- IR
- CMO