Enhancing AAV manufacturing yield through a promoter optimized mini helper plasmid
AAV manufacturing efficiency can be improved through optimized plasmid design and transfection strategies that reduce plasmid DNA input while supporting higher AAV titers.
In this on-demand webinar, Kihyun Park, Ph.D., Lead Scientist in AAV Process Discovery at Samsung Biologics, discusses how a promoter-optimized mini-helper plasmid can improve AAV titers with reduced plasmid DNA input while maintaining particle quality across scales.
Key highlights include:
The design strategy behind the promoter-optimized mini-helper plasmid and how its compact structure can reduce DNA synthesis costs while retaining essential adenoviral helper functions
How optimized transfection conditions using the mini-helper platform can significantly improve AAV titers while reducing total plasmid DNA input
How the mini-helper platform can support next-generation AAV manufacturing strategies, including stable cell line development and dual-vector applications
Discover how innovative plasmid design and process optimization can help advance more efficient and scalable AAV manufacturing.
AAV manufacturing efficiency can be improved through optimized plasmid design and transfection strategies that reduce plasmid DNA input while supporting higher AAV titers.
In this on-demand webinar, Kihyun Park, Ph.D., Lead Scientist in AAV Process Discovery at Samsung Biologics, discusses how a promoter-optimized mini-helper plasmid can improve AAV titers with reduced plasmid DNA input while maintaining particle quality across scales.
Key highlights include:
- The design strategy behind the promoter-optimized mini-helper plasmid and how its compact structure can reduce DNA synthesis costs while retaining essential adenoviral helper functions
- How optimized transfection conditions using the mini-helper platform can significantly improve AAV titers while reducing total plasmid DNA input
- How the mini-helper platform can support next-generation AAV manufacturing strategies, including stable cell line development and dual-vector applications
Discover how innovative plasmid design and process optimization can help advance more efficient and scalable AAV manufacturing.
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